The 2017–2026 E-Class uses the same key setup, so everything on this page applies to those years too. The full picture is on the Mercedes-Benz E-Class key guide.

2021 Mercedes-Benz E-Class: key facts

Key type: Smart / proximity key
Push-to-start: Yes
Transponder chip: FBS4 (DAS4)
Programming: Dealer-only (we'll tell you before you spend anything)
All keys lost: We can originate new keys on site

W213 FBS4 (Abrites documents the W213 EZS as FBS4): added/replacement keys are effectively dealer-only — VIN-coded order and Xentry enablement with the car present. Push-button start standard.

Same key system as the 2017–2026 E-Class

Mercedes-Benz kept the E-Class's key system unchanged across 2017–2026, so everything about replacing a 2021 key — blanks, programming, and what happens if every key is lost — matches the rest of that run. The full year-by-year breakdown lives in our Mercedes-Benz E-Class key guide.

For this generation, added or replacement keys go through the dealer — we say that up front rather than charge you to find out. Call (213) 577-1366 and we'll tell you honestly whether a mobile locksmith or the dealer is the right move for your situation.

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Reviewed by David, Owner & Lead Technician, Wilshire Lock & Key — in the locksmith trade since 1987.

Last updated 2026-10-11.

2021 Mercedes-Benz E-Class key replacement

2021 Mercedes-Benz E-Class: key facts

Same key system as the 2017–2026 E-Class

We cover all these cities